12 BONE MINERAL DENSITY (BMD) EVALUTION IN GIRLS WITH TURNER SYNDROME (TS)

Abstract

Osteopenia is a common sign observed in TS. The published results about EMD in these patients are controversial. In order to ctetermine whather osteopania is due to an estrogen deficiency, we evaluated the EMD in 2 groups of patients with TS. The results were compared with those of pre and EMD-pubartal normal controls. Group 1 (G1) :20 patients between 5 and 18 years of age without hormonal therapy, divided in 5 sub-groups, ages 4-6.9;7-9.9;10-12.9;13-15.9;16-18.9 years. Group 2 (G2): 6 patients between 16 and 18 years under hormone therapy (estrogens + progesterone). EMD was measured at the radius shaft (RS) and lumbar spine (LS) (L2-LA) by single and dual photon absorptiometry respectively. The results showed that LS EMD was lower in the TS 10-12.9 years sub-group: (X+SD) 0.758±0.08 gr/cm², compared with the matched age control group: 0.874±0.09 gr/cm² (p< 0.05). Furthermore, 2 patients with chromosomal mosaicism and spontaneous complete pubertal development, showed a EMD 15% lower than matched normal controls. In G2 we observed that both RS and LS EMD were significantly decreased = RS 0.570±0.08 vs 0.647±0.01 gr/cm² (p/.0.01) and IS EMD 0.903±0.09 vs 1.185±0.1 gr/cm² (p<0.005). These data shows that TS patients have a diminished bone mineral density, that could be due to an estrogen deficiency an to the intrinsic feature of TS genetically determined.

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