Abstract
To evaluate lipid peroxidation in the clinical course of e+HUS we investigated plasma of dialysis-dependent children (n= 6;Hb 8,7 +/-1.7 g/dl;platelets 134 +/-117/nL;SCR 4.9+/-0.3 mg/dL;LDH 3402 +/-810U/L) longitudinally from start of dialysis (day 0) up to maximally H weeks α - TOC (mg/g total lipids)(EFA(weight %) and polyunsaturated fatty acids (weight %; PUFA). (age Batched controls = K; N=11)
In consequence of lipid peroxidation α - TOC, PUFA and thereby EFA were decreased on day 0. They only gradually increased in that way as hemolysis decreased and levelled into the normal range after the disappearance of thrombocytopenia and oliguria. Especially the increase of PUFA up to day > 28 correlated well with the decrease of LDH-activity(219 +/- 52 U/L), demonstrating to hemolysis due to peroxidation of fatty acids of the membrane. Since EFA are essential for cell- and membrane synthesis a protracted course of hemolysis in e+HUS might be the consequence of an EFA deficiency. In this case EFA substitution might be able to shorten the clinical course of e+HUS. University Children's Hospital Hamburg, F.R.G.
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Amon, O., Hübner, C., Finckh, B. et al. PROTRACTED DEFICIENCY OF α-TOCOPHEROL (α- TOC) AND ESSENTIAL FATTY ACIDS (EFA) IN ENTEROPATHIC HEMOLYTIC-UREMIC SYNDROME (e+HUS). Pediatr Res 32, 625 (1992). https://doi.org/10.1203/00006450-199211000-00123
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DOI: https://doi.org/10.1203/00006450-199211000-00123
