Abstract
Forty % of sudden infant death syndrome (SIDS) babies have higher hypoxanthine (Hx) cone, in their vitreous humor than respiratory distress syndrome (RDS) babies (unpublished data). To investigate this, the consentrations of Hx and xanthine (X) in plasma, cerebrospinal fluid, urine and vitreous humor were measured in two groups of pigs. One group (n=10) were subjected to intermittent hypoxameia (IH) at intervals: 5 min. FiO2=0.21 and 10 min. FiO2=0.08, while one group (n=9) were subjected to continous hypoxaemia (CH), inspired oxygen FiO2=0.08.
Comparison of Hx-increases after 60 min. of hypoxaemia.
These findings may support our suggestion that SIDS babies experience a stepwise/intermittent type of respiratory failure prior to death rather then the continous type seen in most RDS-cases.
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Stoltenberg, L., Rootwelt, T., Rognum, T. et al. CHANGES IN THE PURINE METABOLISM IN PIGLETS SUBJECTED TO INTERMITTENT OR CONTINOUS HYPOXEMIA. Pediatr Res 32, 629 (1992). https://doi.org/10.1203/00006450-199211000-00148
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DOI: https://doi.org/10.1203/00006450-199211000-00148
