Abstract
Ten patients with anorchia were treated with testosterone undecanoate (40 or 80mg/d) starting at the mean age of 11.5 years (range: 10 - 14 years). The effect on Tanner stage development, growth velocity and weight gain are presented. Therapy was started with 40mg 3x/week (n= 4), 40mg 7x/week (n=6), and was increased to 80mg 7x/week (n=9). Therapy was continued for 23.7 months (range: 14 - 40 months). Stretched penile length before therapy was x = 3.35cm (range: 2.5 - 4cm), at the end of therapy 6.25cm on average (range: 5 - 8cm). Pubic hair Tanner stage 2 (PH2) was achieved after 6.7 months (range: 4 - 14 months) PH3 after 20 months (range: 12 - 29 months). Growth velocity increased to 6.7cm/year (range: 3 - 9cm/year) in the first year of treatment, concomitant weight gain was 7.2kg (range: 5.2 - 10kg). No side effects of treatment were observed. We conclude that oral testosterone undecanoate therapy starting at the age of 11 years with 40mg/d for one year and 80mg/d for a second year is simple, safe and effective and provides for a gentle induction of puberty in anorchid boys.
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Schmidt, H., Knorr, D. & Schwarz, H. EFFECT OF ORAL TESTOSTERONE UNDECANOATE ON TANNER STAGE DEVELOPMENT GROWTH VELOCITY AND WEIGHT GAIN IN ANORCHID BOYS. Pediatr Res 33 (Suppl 5), S16 (1993). https://doi.org/10.1203/00006450-199305001-00076
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DOI: https://doi.org/10.1203/00006450-199305001-00076
