Abstract
We reviewed the endocrine and surgical outcome of 34 cases (23 boys, 17 girls mean age 8.8 yrs) of craniopharyngioma (C) initially operated on from 1980-89. One died, 11/31 who had attempted total removal had a recurrence, 12 have required no further procedures. 7 were followed elsewhere. Of 3 partial removals, 2 recurred. Vision improved in 48% new visual loss 18%, new field defects 24%. Adrenal insufficiency 89%. Hypothyroidism 96% and hypogonadism 100%. Diabetes insipidus occurred in 32, permanent in 31 Postop hyperglycemia 7, 2 required insulin temporarily Mean preop height Z score was - 1.1 (-3.8 to -0.39) 24% were below the 3rd % Mean preop weight Z score was 0.21(-2.9 to +8.4) 16 cases became obese (increase in weight of > 1 Z score) 4/ 17 with and 8/17 without increase in weight Z score required growth hormone(GH). On GH height Z scores improved - 1.8 ± 0.38 to -0.8 ± 0.33(p<0.06 NS).
Conclusions Following attempted total removal of C almost all were hypopit, half became obese and 1/3 recurred. Most obese patients did not require GH
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Curtis, J., Ehrlich, R., Daneman, D. et al. ENDOCRINE OUTCOME OF SURGICAL REMOVAL OF CRANIOPHARYNGIOMAS. Pediatr Res 33 (Suppl 5), S29 (1993). https://doi.org/10.1203/00006450-199305001-00156
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DOI: https://doi.org/10.1203/00006450-199305001-00156
