Abstract
In 1987 a multicenter trial was started to evaluate the effect of daily s.c. rhGH treatment (0.15 IU/kg/day Genotonorm, Kabi Pharmacia, Sweden) in 40 girls with Turner syndrome (TS) (mean±SD age: 11.3±2.6 yrs). Twenty randomly selected girls received in addition 25 ng/kg/day ethinylestradiol (EE2) orally. From the 3rd year of treatment puberty was induced with 100 ng/kg/day EE2 in the girls with a bone age older than 11 years. Thirty-six patients have been followed for 5 years. Except early breast budding in 9 out of 20 girls treated with rhGH and 25 ng/kg/day EE2, no differences were found between the patients treated with rhGH alone and those also treated with low dose EE2. In 28 patients with a bone age above 13 yrs, height attained 5 years after the start of rhGH treatment is 150.5±4.4 cm. This is higher (P<0.001) than the adult height of 144.8±5.8 cm of 43 untreated TS girls. In these 28 girls, the difference in height attained after 5 years of treatment and corrected mid parental height is 10.8±4.8 cm, which is less (P<0.001) than in untreated adult TS patients (16.2±4.8 cm). These results provide further evidence that treatment with rhGH increases final height in TS girls.
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Massa, G., Maes, M., Malvaux, P. et al. GROWTH PROMOTING EFFECT OF GROWTH HORMONE AND LOW DOSE ETHINYL ESTRADIOL IN GIRLS WITH TURNER SYNDROME: FINAL HEIGHT RESULTS. Pediatr Res 33 (Suppl 5), S56 (1993). https://doi.org/10.1203/00006450-199305001-00319
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DOI: https://doi.org/10.1203/00006450-199305001-00319
