Abstract
The aim of our study was to investigate the effects of GH on neurotensine (NT) levels. Plasma samples were obtained from 7 GH-deficient; children (5 boys, 2 girls), are range 1.1-11.5 years (11.23±l.75 mean ± SKM) to evaluate NT and GH value:;, before treatment and 12 and 24 hours after a subcutaneous rhCH injection (0.15 I.U/kg). NT concentrations were measured by RIA and expressed as fmol/ml; GH values were evaluated by RIA using commercial kits and expressed as ng/ml. NT levels in our pts before GH administration (3.20±1.72 fmol/ml.) were significantly lower (p<0.01) than those in controls (17±2.5 fmol/ml). A significant increase in NT values were found 12 h (39.57±10.42 fmol /ml, p<0.01) and 24 h (13.64±5.28 fmol/ml, p<0.05) after GH injection. Circulating GH concentrations significantly increased (p<0.005) 12 h (2.02±1.23 vs 12.56±2.18 ng/ml), but not 24 h after GH administration (0.74±0.17 ng/ml). We observed a close correlation between NT and GH values before treatment (p<0.005) and at the 24th h after GH injection (p <0.05), but not at the 12th h. Our preliminary results point to a stimulating effect of GH on NT release by mechanism; still unknonw. The GH-induced NT release could be due to an increase in NE-FA concentrations.
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Schimpff, R., Gourmelen, M., Lhiaubet, A. et al. EFFECT OF GROWTH ADMINISTION OF NEUROTENSIN RELEASE. Pediatr Res 33 (Suppl 5), S64 (1993). https://doi.org/10.1203/00006450-199305001-00368
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DOI: https://doi.org/10.1203/00006450-199305001-00368
