Abstract
Daily injections of rhGH and infusions of rhIGF-1 have additive effects on body growth in GH-deficient rats. We now measure growth responses to a fixed daily dose of rhGH (240 μg/d, sc injection) given once or twice daily, with or without rhIGF-1 (120μg/d, sc infusion) for 8 d in female dw/dw rats (6-8 weeks old, 100 g). Rats were sacrificed on Day 8; organs weighed and serum and tibia taken. Data in the Table are means ± SD (n=5/group).
For weight gain, cartilage and relative liver growth bid rhGH gave larger responses than daily rhGH. Spleen growth and serum IGF-I were optimal with rhIGF-1 alone. Combination treatment gave greater weight gain and higher serum IGF-I's but not greater cartilage, liver or spleen growth. We conclude that when rhGH is given in an optimal pattern at high doses additive whole body anabolic effects of rhGH and rhIGF-1 are observed.
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Mortensen, D., Carlsson, L. & Clark, R. COMBINED TREATMENT WITH RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I (rhIGF-I) AND GROWTH HORMONE (rhGH) IN THE DWARF RAT. Pediatr Res 33 (Suppl 5), S65 (1993). https://doi.org/10.1203/00006450-199305001-00369
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DOI: https://doi.org/10.1203/00006450-199305001-00369
