Abstract
The increased incidence of glucose intolerance in Turner syndrome leads to an abnormal GTT in 30-60% of adult women. Since currently explored therapies to increase adult height may impair carbohydrate metabolism we evaluated the effect of more than 3-6 yrs. of GH alone or in combination with oxandrolone on glucose metabolism. The trial was begun in 1983 (n=71) and study subjects receive currently hGH 0.375 mg/kg/wk either in equal daily doses or tiw (hGH) or hGH in combination with oxandrolone 0.0625 m/kg/day (combination). Based on Natl. Diabetes Data Group criteria 15% (11/71) had impaired GTT at baseline. Postprandial insulin results before treatment and after 3 to 6 years of therapy are summarized below. Geometric means (U/ml) are used because of inherent skewness.
The change from baseline to long-term to follow-up was significant in the hGH group (p<0.015) and in the combination group (p<0.0005). The change in the combination group was significantly greater than in the hGH group (p<0.0021) using the unequal variance two sample t-test. There was no difference in Hgb A1C, pre and postprandial glucose, and cholesterol or triglyceride values in the 2 groups. No difference in any of the parameters was seen between hGH tiw or daily.
In summary: Oxandrolone treatment increases insulin resistance in Turner syndrome. The long-term risk from tolerance is unclear at present.
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Almaguer, M., Saenger, P., Frane, J. et al. SIX YEAR DATA OF CARBOHYDRATE TOLERANCE IN TURNER SYNDROME TREATED WITH GROWTH HORMONE AND OXANDROLONE. Pediatr Res 33 (Suppl 5), S67 (1993). https://doi.org/10.1203/00006450-199305001-00381
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DOI: https://doi.org/10.1203/00006450-199305001-00381
