Abstract
From June 1987 until December 1991 we screened a countrywide random sample of 90,228 newborns for 21 OHD measuring 17 α - OR progesterone (17 OHP) form blood spotted on filter paper, 2 Arabs and 1 Jew, were detected with levels of 17 OHP between 135 - 315 ug ml. Suggesting very low incidence of 1 in 30,000 live birth. In order to compare these findings to the incidence of 21 OHD in the total population born in Israel during the years 1986-1991, and if we missed infants who were among those who were screened, all the archives of the hospitals in the country. The incidence of 21 OHD natiowide was 1 : 19,000, 1 : 30,000 for the Jews and 1 : 8,000 for the Arabs. The incidence of 21 OHD among Arab newborns in the northern part of the country was even higher 1 : 5,000 (14 : 71130). The M/F ratio was 1:2.6 and the ratio of salt-wasting to simple virilizing was 5:1. Two male patients were diagnosed month after birth and 6 others subsequently.
Conclusion: The high ratio of F/M suggests that male patients were missed or died early due to salt-wasting. The high incidence of this disease in the northern part of the country and among the Arabs, suggests that screening in this part of the country is warranted.
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Front, H., Schreiher, M. & Sack, J. 21-HYDROXYLASE DEFICIENCY SCREENING AND INCIDENCE IN ISRAEL, 1986–1991. Pediatr Res 33 (Suppl 5), S72 (1993). https://doi.org/10.1203/00006450-199305001-00415
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DOI: https://doi.org/10.1203/00006450-199305001-00415
