Abstract
Up to 1983, placental insufficieny used to be treated by glucose infusions to the mother. We performed a clinical investigation and an oral glucose tolerance test (OGTT) in 20 children, aged 4.9 to 10.5 years, whose mothers underwent a minimum of 8 i.v. infusions with 2000 ml of 10 % glucose during pregnancy because of suspected placental insufficiency (GT-group). 20 of formerly small for gestational age children without a history of glucose infusions were counterparted as matched pairs (NON-GT group). The children of the NON-GT-group were significantly smaller, lighter, showed a lower head circumference and a marked retardation of bone age. The OGTT showed unexpected results: a disturbed glucose tolerance was found in 14 (70 %) patients of the GT-group and in (45 %) patients of the NON-GT-group. The insulin response was normal in only 2 (10 %) of the GT-group and in 5 (25 %) patients of the NON-GT-group. These results could support recent findings that reduced growth in early life is strongly linked with impaired glucose tolerance and appearance of diabetes mellitus.
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Keller, E., Mehlhorn, E., Pätz, E. et al. GROWTH, DEVELOPMENT AND CARBOHYDRATE TOLERANCE OF FORMERLY SMALL FOR GESTATIONAL AGE INFANTS WITH AND WITHOUT GLUCOSE INFUSION THERAPY. Pediatr Res 33 (Suppl 5), S77 (1993). https://doi.org/10.1203/00006450-199305001-00445
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DOI: https://doi.org/10.1203/00006450-199305001-00445
