Abstract
Many factors have been invoked for the cause of pubertal IR, including GH, SS, and increasing adiposity. To determine the respective roles of GH and SS in mediating IR, we studied 24 boys with delayed puberty before and after random assignment to one of 4 research groups: Control (Ctrl), Testosterone (T) Rx, GH Rx, GH + T Rx. We quantitated the insulin sensitivity index (IS) via the mininal model approach. GH was measured Q 20 min from 2000 through 0600 via the Hybritech assay.
Body mass index did not change with GH, but increased significantly with T, and T +GH. Paired ANOVA, and analysis of covariance of the data indicate that IR is highly correlated with GH, but not with T. GH is stimulated by T. We conclude that GH is the predominant factor responsible for the IR of puberty. (Funded by Genentech, Inc., and NIHCRC Grant #RR-69).
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Bloch, C., Klingensmith, O. & Papanti, F. INSULIN RESISTANCE (IR) OF PUBERTY IS MEDIATED BY GROWTH HORMONE (OH) AMD NOT BY SEX STEROIDS (SS): STUDIES IN BOYS WITH DELAYED PUBERTY. Pediatr Res 33 (Suppl 5), S87 (1993). https://doi.org/10.1203/00006450-199305001-00505
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DOI: https://doi.org/10.1203/00006450-199305001-00505
