Abstract
After tracheal instillation of S, changes of blood pressure (BP) and of cerebral blood flow velocities have been observed.
Can such circulatory disturbances be avoided by instillation of MSD? Are oxygenation and pulmonary S distribution affected by this instillation method?
In 9 adult rabbits, respiratory distress was induced by repeated saline lung lavages (until PaO2 was <80 mmHg with FiO2 = 1.0). S(Curosurf) labelled with colored microspheres (CMS) was instilled either as B (1 × 200 mg/kg) or as MSD (5 × 50 mg/kg). Arterial blood gases and BP were monitored. To determine S distribution, the lungs of each animal were cut into 60-70 pieces to measure the number of CMS in each piece.
After B, PaO2 increased to >300 mmHg within 2 min and remained stable. Mean BP dropped transiently from 89±2.1 to 62±6.0 mmHg (mean±SEM). Pulmonary S distribution was fairly homogeneous. After MSD, PaO2, rose stepwise to >300 mmHg, but decreased again after 1 h. BP dropped from 91 ± 2.1 to 75 ± 10 mmHg. S distribution was very uneven.
With MSD of S instead of one bolus, BP changes cannot be avoided; an even S distribution was not achieved. In spite of a satisfactory initial increase of PaO2, this beneficial effect of S was transient.
Sponsored by Deutsche Forschungsgemeinschaft, DFG Ob 43/6-1
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Segerer, H., Van't veen, A., van Gelder, W. et al. EFFECTS OF MULTIPLE SMALL DOSES (MSD) OF EXOGENOUS SURFACTANT (S) VS. ONE BOLUS (B) IN SURFACTANT-DEFICIENT RABBITS. Pediatr Res 35, 277 (1994). https://doi.org/10.1203/00006450-199402000-00134
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DOI: https://doi.org/10.1203/00006450-199402000-00134
