Abstract
Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal complication in leonates. We investigated the effect of BN 50727 and BN 50730, two hetrazepine-type platelet-activating factor (PAF)-antagonists, on the development of NEC in asphyxiated newborn piglets. Animals (3 groups, n = 8 in each) were pretreated 1 h prior to the experiments with (1) BN 50727, (2) BN 50730, or (3) vehicle only (doses were 50 ng/kg for both drugs in 5 ml/kg vehicle, in gastric tube). 1 h after the induction of bilateral pneumothorax, in the critical phase (arterial hypotension, bradycardia, hypoxaemia, and combined acidosis), the piglets were resuscitated and a 24 h-recovery period was allowed to them. BN 50727 administration resulted in moderate decreases n postasphyxial tachycardia and hypertension, increased superior mesenteric artery flow, and improved oxygen saturation in the first hour of reperfusion. There were no similar changes in clinical parameters after BN 50730 treatment. Both PAF-antagonist significantly (p < 0.001) reduced the degree of histological injuries, determined by the modified method of Schneider et al (1987; Pedialr Res 21:422), in the crypts and villi of small intestine (duodenum, jejunum, ileum) of piglets 24 h after the asphyxia. In conclusion, BN 50727 and BN 50730 have a protective effect during neonatal NEC.
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Aabrahám, C., Vágvölgyi, J., Tarrade, T. et al. 1 PLATELET-ACTIVATING FACTOR IS INVOLVED IN THE PATHOGENESIS OF NECROTIZING ENTEROCOLITIS IN ASPHYXIATED NEWBORN PIGLETS: PROTECTIVE EFFECT OF BN 50727 AND BN 50730. Pediatr Res 36, 1 (1994). https://doi.org/10.1203/00006450-199407000-00001
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DOI: https://doi.org/10.1203/00006450-199407000-00001
