Abstract
Intracerebral hemorrhage (ICH) possibly induces damage to surrounding cerebral tissue by ischaemia which may cause severe neurological sequelae, mainly cerebral paresis.
Methods: We have measured regional CBF within the first days after diagnosis (1-3days) in 6 preterm infants (GA 26-29weeks) with unilateral ICH and in 9 preterm infants (GA 26-32weeks) without ICH using single photon emission computer tomography and 99mTc-HMPAO (Ceretec®) i a dose of 4MBq/kg. We used a 4-head fast rotating gamma camera (Tomomatic 248®) with a spatial resolution of 6×6×8mm.
Results: Compared to the control group the flow to the white matter of the affected hemisphere was decreased 37% (p=0.0003, non-paired t-test). The flow to the other regions did not differ significantly but the flow to the grey matter of both hemispheres and to the basal ganglia of the affected hemisphere showed a higher variation than the control group (p<0.01, F-test).
Conclusion: Similar to former studies in premature infants we have demonstrated a decreased white matter flow in the affected hemisphere. In contrast, flow abnormalities was seen in the grey matter of both hemispheres. This indicates that ICH may be a part of a more widespred brain damage and; may explain the variation in neurological outcome.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Borch, K., Greisen, G. 25 WIDESPREAD REGIONAL CEREBRAL BLOOD FLOW DISTURBANCES IN PRETERM INFANTS WITH INTRACEREBRAL HEMORRHAGES. Pediatr Res 36, 7 (1994). https://doi.org/10.1203/00006450-199407000-00025
Issue date:
DOI: https://doi.org/10.1203/00006450-199407000-00025
