Abstract
Iron-induced oxidative stress may play a role in postasphyxial reperfusion injury. We serially measured free iron (bleomycin assay) and TBARS (index of lipid peroxidation) in plasma of 50 term neonates in the first 24 h after birth. We compared 20 healthy newborn (HN) with 15 moderately asphyxiated newborns (MAN), and 15 severely asphyxiated newborns (SAN) with abnormal neurological signs in the first 24 h of life.
Results: Cord pHs were 7.29±0.09, 7.02±0.08 and 6.87±0.10 for HN, MAN and SAN. All HN, 14 MAN and 7 SAN had normal neurological examinations at discharge. Eight SAN had brain damage, 5 died in the neonatal period. Liver and renal functions were abnormal in 10 SAN and MAN. Free iron was not detectable in 66% of HN. 20% of MAN, and 12% of SAN. Results are summarized in table:
Conclusion: Neonates with severe birth asphyxia, neurological abnormalities, and abnormal liver and renal tests had increasing plasma levels of free iron and TBARS in the first 24 h of life. This suggests a role for iron-induced lipid peroxidation in the etiology of reperfusion injury after severe birth asphyxia.
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Dorrepaal, C., Benders, M., Houdkamp, E. et al. 58 IRON INDUCED LIPID PEROXIDATION AND REPERPUSION INJURY AFTER SEVERE BIRTH ASPHYXIA. Pediatr Res 36, 12 (1994). https://doi.org/10.1203/00006450-199407000-00058
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DOI: https://doi.org/10.1203/00006450-199407000-00058
