162 Acute Blood Pressure Effects of Surfactant Replacement in Newborn Piglets

Abstract

As part of a study on cerebral blood flow and hemodynamics after replacement therapy with a natural porcine surfactant, we present preUminary data on acute changes in blood pressure. Three groups of piglets, age 3-6 days chosen to secure closed ductus arteriosus, underwent lung lavage with 0.9% saline. Group 1 was normovolemic and normoxic before surfactant was given. Group 2 was normoxic and made hypovolemic by bleeding 20% of estimated blood volume. Group 3 was normovolemic and hypoxic. Mean blood pressure (MBP) was measured continuously and is given as mean ±SD. ΔMBP is the difference between MBP immediately before surfactant and at lowest MBP after surfactant

Blood pressure decreased significantly in all three groups reaching a minimum value at 4 minutes ±1.5 after surfactant instillation. The blood pressure decreased significantly more in group 2 and 3 than in group 1. MBP was restored to pre-surfactant values within 22 min ±13 min. a/APo₂-ratio decreased significantly in group 2. Later a/APo₂ ratio increased beyond pre-surfactant value in all three groups. We conclude that in normovolemic, normoxic piglets MBP decreased significantly less than in hypovolemic and hypoxic piglets treated with natural porcine surfactant. The change in MBP was independent of changes in pO₂ and not related to a persistent ductus arteriosus.

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