Abstract
Neonates with CDH are exceptionally vulnerable to complications of artificial ventilation such as pneumothorax and bronchopulmonary dysplasia (BPD) because of their reduced lung volumes, demonstrable by measurement of functional residual capacity (FRC) and thoracic gas volume (TGV).
Methods: Serial lung function tests were performed in three infants with CDH, including single occlusion tests, nitrogen washout measurement of FRC (SensorMedics 2600, USA), and determination of TGV (Jaeger Baby-Bodyplethysmograph).
Results: Two neonates with right-sided CDH showed appropriate increase of initially low respiratory system compliance, FRC, and TGV shortly after operation. The remaining infant had left-sided CDH and developed severe BPD accompanied by extremely low compliance and FRC, and elevated resistance and TGV values.
Conclusions: Serial measurement of both FRC and TGV permits early detection of lung overinflation in infants with CDH threatened by BPD. Our results are consistent with reports indicating a better prognosis for right-sided CDH in regard of lung function.
*) supported by BMFT-project “Risikoneugeborenes”
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nowotny, T., Maurer, T., Ahrens, B. et al. 180 LUNG VOLUMES AND LUNG MECHANICS IN NEONATES AND INFANTS WITH CONGENITAL DIAPHRAGMATIC HERNIA (CDH). Pediatr Res 36, 32 (1994). https://doi.org/10.1203/00006450-199407000-00180
Issue date:
DOI: https://doi.org/10.1203/00006450-199407000-00180
