Abstract
Adherent strains of coagulase negative staphylococci (C-NS) were reported to be more pathogenic and resistant to antibiotics and to appear later during hospitalisation than non-adherent ones. Aim of this prospective study was to correlate adherence of C-NS with clinical sepsis and antibiotic resistance and to correlate the time of appearance of adherent with non-adherent strains. Sixty-one C-NS strains isolated from blood cultures in 55 new-borns between 1991 and 1993 were included in the study. Adherence was determined according to the qualitative method of Christensen (1982).
Of 61 episodes of positive blood cultures 38 (62%) strains had adherence test positive, 41/61 (67%) of episodes were associated with clinical and laboratory signs of sepsis. Of C-NS with positive adherence 28/38 were associated with sepsis, whereas in C-NS with negative adherence 13/23 were associated with sepsis (differences NS, p=0.27). Of C-NS with positive adherence 31/38 were resistant to at least three antibiotics (methicillin, geniamycin and chloramphenicol), whereas in C-NS with negative adherence 13/23 were resistant to antibiotics (differences NS, p=0.069). No difference was found in the median day of appearance between adherent and non-adherent strains (6th vs. 13.5 th day, p=0.415). In this study we did not find significant differences between adherent and non-adherent strains of C-NS.
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Derganc, M., Gubina, M., Dragas, A. et al. 361 THE CLINICAL SIGNIFICANCE OF TESTING FOR ADHERENCE IN COAGULASE- NEGATIVE STAPHYLOCOCCI. Pediatr Res 36, 63 (1994). https://doi.org/10.1203/00006450-199407000-00361
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DOI: https://doi.org/10.1203/00006450-199407000-00361
