Abstract
Turner Syndrome (TS) is associated with multiple malformations and skeletal abnormalities, including an alteration in bone mineralization (BM), present since infancy. We were interested in evaluating the current state of BM in TS patients. 30 patients (6 8/12 - 17 3/12 years) with cariotype certification of TS were studied. Antropometric characteristic were evaluated at birth and at the time of the study. In all of them, BM of whole body, spine and hip (femoral neck, trocanter and Ward's triangle) was performed using adual photon isotopic densitometer (Norland). They were compared with 93 normal girls of same ages. TS patients had lower weight and height at birth, a lower H/A and higher W/H adequation than controls, with significant difference. The percentage of adequations of BM of whole body in total bone mass (TBM) and bone mineral density (BMD) was significatively lower than in controls (63,0 ± 12,8 vs. 100,0 ± 18,6 and 87,3 ± 10,4 vs 100,1 ± 10,8 respectively). At spine level there were significative differences in TBM, BMC and BMD (72,2 ± 15,2 vs 100,0 ± 19,8; 81,1 ± 15.3 vs 100,0 ± 16,2 and 89,5 ± 16,2 vs 100,0 ± 15.7 respectively). In hip (neck, trocanter and Ward's triangle) the same high significative differences were observed. Stratificating the patients according to age, those under 10 6/12 years have a significantly lower BM, being these girls a risk group of severe osteoporosis and fractures in adult life.
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Burgueño, M., Burrows, R., Leiva, L. et al. 16 BONE MINERALIZATION IN PATIENTS WITH TURNER SYNDROME.. Pediatr Res 36, 680 (1994). https://doi.org/10.1203/00006450-199411000-00074
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DOI: https://doi.org/10.1203/00006450-199411000-00074
