Abstract
Low doses of MTX have been used in the treatment of corticodependent asthmatic children. The association of MTX to regular treatment has been shown to reduce the amount of oral steroids and sometimes its complete withdrawal, problaby due to its anti inflammatory effects. We studied MTX treatment (0.06 mg/kg/week) in 5 allergic asthmatic corticodependent (oral prednisone) children ( 6 to 14 years old) during a 5 months period. The regular medication was mantained (long acting theophylline, beta 2 agonists, ipratropium bomide, beclomethasone dipropionate) during the period of study. The children were evaluated at 15 days intervals and the prednisone dose was reduced after clinical and pulmonary function tests (PFT).
* % of the original dosage. A reduction in the prednisone dose, mild improvement in the PFT and no side effects during MTX treatment was observed. We concluded that MTX could be a reasonable addition for the treatment of asthmatic corticodependent children.
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Solé, D., Salto, J., Vagnozzi, V. et al. METHOTREXATE (MTX) IN THE TREATMENT OF CORTICODEPENDENT ASTHMATIC CHILDREN. Pediatr Res 36, 824 (1994). https://doi.org/10.1203/00006450-199412000-00032
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DOI: https://doi.org/10.1203/00006450-199412000-00032
