The purpose of our study was to evaluate the developmental changes in fetal blood bilirubin binding capacity. Patients were divided in two groups: 47 term(BW=3172±393g, GA=39.5±1.1 weeks) and 39 preterm infants(BW=2012±467g; GA=34.1±1.9 weeks). Cord blood was drawn and enriched with six bilirubin concentrations: 5, 10, 15, 20, 25 and 30 mg/dl.

Total bilirubin - B (Jendrassik-Gróf), serum albumin - A (bromcresol green) and free bilirubin - FB (horseradish peroxidase) were measured and the following parameters were compared between term and preterm cord sera: B× FB and bilirubin/albumin molar ratio B/A × FB.

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