INDO prophylaxis may reduce incidence of IVH in preterm infants. INDO reduces CBFV. Hypothesis: The fall in CBFV after IV INDO is associated with PDA closure. Methods: Continuous recording of CBFV by transcranial pulsed doppler ultrasound, for 30 min. before, and 120 min. after, IV INDO given for hemodynamically significant PDA (n = 12); simultaneous recording of arterial O2 saturation, BP, heart rate and TcPCO2. Echocardiography at 120 min (n = 11). Results: INDO did not change BP. CBFV fell for up to 120 min (maximum 45%, P<0.001); pulsatility index (PI) rose (maximum 77%, P<0.05). Closure of PDA at 120 min. was associated with fall in CBFV (P<0.05) and increase in BP/CBFV ratio (P<0.0001). High LA/AO ratio at 120 min. was associated with rise in PI (P<0.01) and fall in CBFV (P<0.05). Large residual PDA was associated with fall in CBFV (P<0.02), rise in PI (P<0.01), and rise in BP/CBFV ratio (P<0.0001). Conclusions: Effects of INDO on CBFV depend on PDA status. Effects of early INDO prophylaxis on CBFV deserve further investigation.

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