Endothelial Acid Phosphatase May Participate in the Histamine-Induced Vasogenic Brain Oedema Formation in Newborn Pigs 137

Background: Histamine plays a role in postasphyxial brain oedema formation. We investigated the effect of intracarotid histamine injection on blood-brain barrier permeability (BBBP) and acid phosphatase (APase, EC 3.1.3.2) activity in brain tissue and isolated cortical microvessels (MV).

Subjects: 48 anesthesized newborn pigs (4-8 h; 1,070-1,560 g).

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD