We tested anti-polio antibodies titer and delayed hypersensitivity (DHS) to tetanic and diphteric antigens (Multitest-Merieux) in 80 children (42 M, 38 F), aged between 22 and 170 months (median: 103 months), off-therapy for onco-haematologic diseases, to evaluate persistence of immunologic memory after chemotherapy. The immunologic control was performed between 1 month and 55 months (median: 32 months) after stop-therapy. Moreover, we tested immunologic reactivity of those patients who appeared non immune, therefore ulteriorly vaccinated against poliomyelitis, tetanus and diptheria.

46 patients had been treated for ALL (26 cases medium risk, 20 high risk); 5 children had AML, 9 NHL, 4 HL, 4 Histiocithosis, 3 RMS, 3 NB, 2 Wilms' Tumor, 4 other neoplastic diseases; 8 of these patients underwent BMT (3 allogenic BMT, 5 autologous BMT). All patients had been previously protected according to national obligatory vaccination plans.

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