Cerebral Hemodynamics and Oxygenation Following Surfactant Treatment in Preterm Infants: Comparison Between Two Different Doses. • 978

Introduction Contrasting evidences exist regarding the possible effects of surfactant administration on cerebral perfusion. Aim of this study was to compare changes in cerebral hemodynamics and oxygenation following a 100 mg/kg and 50 mg/kg dose of bovine surfactant.

Methods 17 Infants of mean gestational age (GA) 29 ± 2.7 weeks (24-35), mean birth weight (BW) 1078 ± 358 g (600-1840), received a 100 mg/kg bolus dose of bovine surfactant (Alveofact); 8 infants of GA 29.2± 2.2 weeks (26-32), BW 1123 ± 406 g (660-1650) received 50 mg/kg of natural surfactant. Near infrared spectroscopy (NIRS-NIRO Hamamatsu Photonics KK) was used to assess relative changes in oxyhemoglobin(ΔHbO₂), deoxyhemoglobin (ΔHb), oxidized cytochrome aa₃ (ΔCytO₂) and cerebral blood volume (ΔCBV), derived from total hemoglobin (HbT). Changes were calculated at 1, 5, 15, 30 and 60 minutes after surfactant administration.

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