Several treatments have been used in order to overcome chemotherapy-induced neutropenia that may cause increased morbidity and mortality in cancer patients. We aimed to determine the effect of different approaches for the treatment of neutropenia on hematological parameters and lymphocyte subtypes. Twenty-eight consecutive patients with absolute polymorphonuclear leukocyte(PNL) counts less than 500/mm3 while receiving maintenance of St. Jude Total XI treatment were enrolled in the study. The hematological parameters observed were hemoglobin (Hb), red blood cell (RBC) count, white blood cell(WBC) count, absolute PNL and monocyte (Mo) counts, and platelet count. We also determined total absolute T- and B- cell counts, CD4+ and CD8+ lymphocyte counts and helper/suppressor (H/S) lymphocyte ratio. Results were obtained before treatment and after a week beginning the day the patient received the first dose of treatment. Results were as follows:

1st group: (7 patients; received 5 μg/kg/d G-CSF for 4 days s.c.): Hb level and RBC, WBC, PNL and total lymphocyte counts increased significantly.

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