Objectives of the study: Primary, the evaluation of prevalence of resistance to activated protein C (APCR) in thalassemic patients; secondary, the study of prevalence of thrombosis in a group of polytransfused thalassemic patients.

Patients: We evaluated 82 thalassemia major and 3 thalassemia intermedia patients (48 M, 37 F), median age 17 years. 62/85 pts. were HCV-positive, 3/85 HIV-positive, 19/85 were splenectomized, 16/85 had chronic hepatopathy. 20 normal healthy children were recruited as control group. The number of thrombotic events was retrospectively studied in the last 20 years.

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