Increased Prevalence of Factor V G1,691A (Leiden) Mutation in Neonates with Intracranial Hemorrhage 71

Classic observations indicated that in the development of the intracranial hemorrhage (IH) of neonates fluctuations in arterial pressure, asphyxia, and coagulopathy can be involved. The mutation of factor V Leiden (LM) is associated with activated protein C resistance and ultimately with increased risk for thrombophilia. The relatively high incidence of the LM in the average population had prompted us to analyze the prevalence of the LM in neonates with IH.

We analyzed the DNA of 60 neonates having IH established by repeated ultrasonographies; results of 250 random patients at our NICU served as controls.

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