Homeobox transcription factors influence the expression of multiple genes, thereby regulating patterns of differentiation and cell fate. The Hoxa5, b5 and Hex homeobox genes are actively expressed in fetal rat lung, but little is known of their regulation.

Circulating levels of analogues of butyric acid, a known modulator of gene expression, are elevated in fetuses in diabetic pregnancies. We hypothesized that butyric acid may play a role in the delayed fetal lung maturation which is induced by maternal diabetes and that this effect may, in part, be mediated by homeobox genes. The effects of Na butyrate on morphologic development and homeobox gene expression were examined in explants of fetal rat lung.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD