Pneumonitis following meconium aspiration: neutrophil chemotaxis induced by interleukin-8 present in meconium † 992

Introduction: Pneumonitis, characterized by large numbers of neutrophils, is an important feature of meconium aspiration syndrome (MAS). The mechanism underlying the neutrophil influx is unknown. This study evaluated if meconium was chemotactic and if this was related to the presence of IL-8.

Conclusion: IL-8 in meconium induces chemotaxis of and this mechanism may play a role in the pathogenesis of pneumonitis in MAS.

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