Several studies have demonstrated that immune activation caused by vaccination may result in elevation of HIV viral load. Additionally, poor immunization responses are common in HIV-infected children. We therefore studied serologic responses to influenza vaccination and resulting changes in HIV bDNA (Chiron Inc.) in HIV-infected children. Because vitamin A supplementation may enhance immunization responses in vitamin A deficient children, we also determined vitamin A status in the patients, who were then randomized to receive either vitamin A (2 successive daily oral dosages of 200,000 IU) or placebo 2 weeks before vaccination in a double blind study.

Fifty nine children living in Chicago were enrolled (median age 81 mos., range 25-209; CDC immunologic stages 1: n=12, 2: n=25, 3: n=22). There were no differences between vitamin A and placebo supplemented groups at baseline.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD