Differential Induction of Cytokine mRNA by Gram Negative and Gram Positive Bacterial Infections in a Rabbit Ileal Loop Model of Necrotizing Enterocolitis

Abstract 1195 Poster Session II, Sunday, 5/2 (poster 55)

Elevated levels of proinflammatory cytokines have been demonstrated in blood and tissue samples from babies with NEC. The precise role played by bacteria in such events is not clear. We have previously reported that adherent E. coli can cause NEC-like injury in a rabbit ileal loop model and that Gram (+) bacteria (E. faecium) can block such injury. We also have shown elevated levels of IL-8, IL-1β and IL-1 receptor antagonist (IL-1RA) in E. coli-infected ileal loops.

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