Role of Bacteria and Immunosuppressive Agent in a Weanling Rabbit Ileal Loop Model of Necrotizing Enterocolitis

Abstract 1332 Poster Session II, Sunday, 5/2 (poster 53)

Prematurity, ischemia, bacterial colonization, and substrate have all been implicated in the pathogenesis of Necrotizing Enterocolitis (NEC). Cytokines and other inflammatory mediators have been examined in babies with NEC, in animal models, and have been linked to injury. We have previously reported NEC-like injury in a weanling rabbit ileal loop model using adherent E. coli and blockage of injury upon co-infection with a candidate Gram positive partner (Enterococcus faecium).

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD