Comparative Responses of Cyclic AMP (cAMP) and Substance P (SP) in Premature and Adult Rat Brain Synaptosomes Exposed to Morphine Sulfate (MS) and Morphine-3-Glucuronide (M-3-G)

Abstract 2010

Background: Opioids have been shown to acutely inhibit adenylyl cyclase and decrease cAMP levels in the brain. Loss of opioid-inhibited cAMP generation appears to be associated with production of substance P and developmental of tolerance. The purpose of this study was to examine whether cAMP and SP responses to opioids are related to CNS maturity.

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