Abstract 534 Poster Session II, Sunday, 5/2 (poster 207)

Background: Familial hyperaldosteronism type-II (FH-II) is a dominantly inherited disease characterized by hypertension due to non-glucocorticoid suppressible autonomous hyperaldosteronism arising from either bilateral adrenal hyperplasia or aldosterone-producing adenomas. Diagnostic biochemical features of this disease include an elevated aldosterone and a suppressed plasma renin activity with an aldosterone/renin ratio (ARR) > 25 as well as failure of aldosterone suppression following 4 days of dexamethasone (0.25mg Q6H). Hypokalemia is not a consistent feature. Affected kindreds have been described in several countries although the largest collection published to date has been in Australia. Screening of affected kindreds has identified some normotensive patients who have had abnormally elevated ARR from their second decade of life. We aimed to use linkage analysis to identify candidate gene loci in several large Australian kindreds with FH-II.

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