Abstract
A methylenetetrahydrofolate reductase polymorphism (677 C/T mutation) was recently implicated in the etiology of Down syndrome. We studied a cohort of 85 women carrying fetuses with Down syndrome and found no difference in the frequencies of the three groups of subjects (C/C, C/T, T/T) between Down syndrome mothers and controls.
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Abbreviations
- DS:
-
Down syndrome
- MTHFR:
-
methylenetetrahydrofolate reductase
References
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Supported by the Association Française pour la Recherche sur la Trisomie 21 and the Institut de Recherches Internationales Servier.
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Chadefaux-Vekemans, B., Coudé, M., Muller, F. et al. Methylenetetrahydrofolate Reductase Polymorphism in the Etiology of Down Syndrome. Pediatr Res 51, 766–767 (2002). https://doi.org/10.1203/00006450-200206000-00018
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DOI: https://doi.org/10.1203/00006450-200206000-00018
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