Abstract
Adult thyroid cancers express IGF and IGF-I receptor (IGF-I-R), but the clinical impact is not clear. No previous study examined any childhood thyroid cancers that are well-differentiated and have a favorable prognosis. We used immunohistochemistry to determine IGF-I and IGF-I-R in 23 papillary thyroid cancers (PTC) and 6 follicular thyroid cancers (FTC) from children and adolescents. IGF-I was detected in 45% and IGF-I-R in 43% of cancers. IGF-I and IGF-I-R were found more often in PTC (IGF-I = 9/23, IGF-I-R = 8/19) than normal surrounding thyroid (IGF-I = 0/10, p = 0.032 and IGF-I-R = 0/10, p = 0.030). There were too few FTC to support independent statistical analysis, but IGF-I was found in 4 of 6 FTC (0/10 normal), and IGF-I-R was found in 2 of 4 FTC (0/10 normal). IGF-I-R staining was more intense in aggressive (invasive, metastatic, recurrent, or persistent) than indolent tumors (confined to the gland, p = 0.029). Over time, six tumors recurred, five of which expressed IGF-I-R. Overall recurrence risk was significantly greater for tumors that expressed IGF-I-R (p = 0.05) but only approached statistical significance (p = 0.08) when disease-free survival was determined. We conclude that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I-R. Tumors that express IGF-I-R are more likely to show aggressive clinical features (invasion beyond the capsule, metastasis, or recurrence) and persistence despite treatment.
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Abbreviations
- IGF-I-R:
-
insulin-like growth factor receptor I
- IR:
-
insulin receptor
- ACTUR:
-
automated central tumor registry
- MACIS:
-
metastasis age completeness of resection invasion size
- Tg:
-
thyroglobulin
- FTC:
-
follicular thyroid cancer
- PTC:
-
papillary thyroid cancer
- DAB:
-
diaminobenzadine
- VEGF:
-
vascular endothelial growth factor
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Support for this work was obtained from the Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC.The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or to reflect the opinions of the Uniformed Services University of the Health Sciences, the United States Army, or the Department of Defense.
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Gydee, H., O'neill, J., Patel, A. et al. Differentiated Thyroid Carcinomas from Children and Adolescents Express IGF-I and the IGF-I Receptor (IGF-I-R). Cancers with the Most Intense IGF-I-R Expression May Be More Aggressive. Pediatr Res 55, 709–715 (2004). https://doi.org/10.1203/01.PDR.0000111282.98401.93
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DOI: https://doi.org/10.1203/01.PDR.0000111282.98401.93
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