Abstract
Background: Bronchopulmonary dysplasia (BPD) was recently classified as mild, moderate or severe in step with oxygen (O2) or positive pressure (PP) requirement at 36 wks post conceptional age (PCA).
Objective: To assess pulmonary function at one year of age of premature infants born before 32 wks PCA in step with initial BPD severity. Patients and methods: 25 infants (mean GA±SD = 27.6±1.9 wks; birthweight = 851±174g) with BPD (i.e., O2 requirement for more than 28 days) were classified as mild BPD if weaned of O2 and PP at 36 wks PCA (group1; n=8) and moderate to severe if not (group2, n=16). At 14.3±3.5 months of age (i.e.; 11.7±3.6 months corrected age) functional residual capacity (FRC) was assessed with the nitrogen washout method and the partial forced expiratory flow (Vmax FRC) with the jacket method. Values were expressed as percentage of predicted normal values.
Results: Vmax FRC and FRC of the population studied were 42.6±26.5% and 77.4±14.9% of predicted normal values, respectively. 4 infants (16.7%) had pure restrictive disease (i.e.; FRC < 80% of predicted values), 8 (33,3%) had pure obstructive disease (i.e.; Vmax FRC < 80% of predicted values) and 11 (45%) had both diseases. There was no statistical correlation between any measurements of pulmonary function and birthweight, GA, duration of mechanical ventilation nor duration of oxygen therapy. There was no significant difference in pulmonary function at 1 year of age between the 2 groups.
Conclusion: Infants with a history of BDP exhibited very frequent severe pulmonary function abnormalities at one year of age characterized by airflow obstruction, restrictive disease or both. These abnormalities were no predicted by initial BPD severity.
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Husseini, K., Huon, C., Mokhtari, M. et al. 178 Pulmonary Function at one Year of Age in Premature Infants with Bronchopulmonary Dysplasia. Pediatr Res 58, 385 (2005). https://doi.org/10.1203/00006450-200508000-00207
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DOI: https://doi.org/10.1203/00006450-200508000-00207
