Abstract
Background: The results of experimental studies indicate that the relation between oxygen therapy and the stage of retinopathy of prematurity (ROP) cannot be described by a simple model. Technical progress, new methods of vital signs recording and transmission allow for better, continuous monitoring of the patients status.
Aim: Analysis of correlation between results of continuous monitoring of hemoglobin saturation during the first month of life and the risk of proliferative ROP. Methods: A sample of 26 newborns with mean birthweight 1060g (range: 600-1450g) were evaluated prospectively. Oxygen hemoglobin saturation (spO2) was monitored on the continuous basis and recorded in computer database during the first 4 weeks of life. The infants were divided into 2 groups: A) no ROP (n=20), B) ROP requiring laser or cryotherapy (n=6).
Results: The recorded values during the first week of life were similar in both groups. The differences were recorded in the 2nd-4th week of life. Surprisingly, mean spO2 were higher in the group A (group A vs B: week 2: 96.5 vs 93.7%, week 3: 95.9 vs 93.3%, week: 4: 95.9 vs 93.5%, p<0.02) and the total time (percantage) with spO2>97% (48 vs 17%, 40 vs 20%, 41 vs 21%) was insignificantly higher. The total time (percentage) with spO2<85% (1.2 vs 3.3%, 1.7 vs 6.6%, 1.7 vs 7.7%; p<0,001), mean drop of spO2 from 85% (6.1 vs 6.7%, 4.6 vs 6.8%, 4.8 vs 6.8%; p=0.02) and standard deviation of recorded spO2 values reflecting spO2 fluctation (3 vs 4.3%, 3.4 vs 5.6%, 3.3 vs 5.9%; p=0.03) were higher in the group B infants.
Conclusion: Based on our preliminary study, we recommend that paying special special attention to prevent hyperoxia, we should not forget about preventing hypoxia which seems to be also a major risk factor of ROP.
Study partially supported by Polish Ministry of Science grant No 0642/P05/2003/24
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kwinta, P., Kruczek, P., Stoch, P. et al. 212 Results of Continuos Monitoring of Hemoglobin Saturation During the First Month of Life as Predictors of Retinopathy of Prematurity. Pediatr Res 58, 390 (2005). https://doi.org/10.1203/00006450-200508000-00241
Issue date:
DOI: https://doi.org/10.1203/00006450-200508000-00241
