Abstract
This article reviews recent developments and major issues in the use and design of biomaterials for use as scaffolds in pediatric tissue engineering. A brief history of tissue engineering and the limitations of current tissue-engineering research with respect to pediatric patients have been introduced. An overview of the characteristics of an ideal tissue-engineering scaffold for pediatric applications has been presented, including a description of the different types of scaffolds. Applications of scaffolds materials have been highlighted in the fields of drug delivery, bone, cardiovascular, and skin tissue engineering with respect to the pediatric population. This review highlights biomaterials as scaffolds as an alternative treatment method for pediatric surgeries due to the ability to create a functional cell-scaffold environment.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Langer R 2000 Tissue engineering. Mol Ther 1: 12–15
Langer R, Vacanti JP 1993 Tissue engineering. Science 260: 920–926
Vacanti JP, Langer R 1999 Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet 354: SI32–SI34
Cima LG, Vacanti JP, Vacanti C, Ingber D, Mooney D, Langer R 1991 Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng 113: 143–151
Demann ET, Stein PS, Haubenreich JE 2005 Gold as an implant in medicine and dentistry. J Long Term Eff Med Implants 15: 687–698
Ratner BD, Bryant SJ 2004 Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng 6: 41–75
De Laporte L, Shea LD 2007 Matrices and scaffolds for DNA delivery in tissue engineering. Adv Drug Deliv Rev 59: 292–307
Frimberger D, Lin HK, Kropp BP 2006 The use of tissue engineering and stem cells in bladder regeneration. Regen Med 1: 425–435
Harrison BS, Eberli D, Lee SJ, Atala A, Yoo JJ 2007 Oxygen producing biomaterials for tissue regeneration. Biomaterials 28: 4628–4634
Nakabayashi N 2003 Dental biomaterials and the healing of dental tissue. Biomaterials 24: 2437–2439
Raghunath J, Rollo J, Sales KM, Butler PE, Seifalian AM 2007 Biomaterials and scaffold design: key to tissue-engineering cartilage. Biotechnol Appl Biochem 46: 73–84
Earthman JC, Li Y, VanSchoiack LR, Sheets CG, Wu JC 2006 Reconstructive materials and bone tissue engineering in implant dentistry. Dent Clin North Am 50: 229–244 ix
Chalasani R, Poole-Warren L, Conway RM, Ben-Nissan B 2007 Porous orbital implants in enucleation: a systematic review. Surv Ophthalmol 52: 145–155
Gilbert TW, Stewart-Akers AM, Badylak SF 2007 A quantitative method for evaluating the degradation of biologic scaffold materials. Biomaterials 28: 147–150
van Amerongen MJ, Harmsen MC, Petersen AH, Kors G, van Luyn MJ 2006 The enzymatic degradation of scaffolds and their replacement by vascularized extracellular matrix in the murine myocardium. Biomaterials 27: 2247–2257
Hollister SJ, Maddox RD, Taboas JM 2002 Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials 23: 4095–4103
Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans GR, Brandt K, Savel T, Gurlek A, Patrick CW Jr, Mikos AG 1998 Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 19: 1945–1955
Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM 2001 A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behavior. Biomaterials 22: 883–889
Thornton AJ, Alsberg E, Hill EE, Mooney DJ 2004 Shape retaining injectable hydrogels for minimally invasive bulking. J Urol 172: 763–768
Li X, Jin L, Balian G, Laurencin CT, Greg Anderson D 2006 Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineering. Biomaterials 27: 2426–2433
Patel M, Vandevord PJ, Matthew H, Wu B, DeSilva S, Wooley PH 2006 Video-gait analysis of functional recovery of nerve repaired with chitosan nerve guides. Tissue Eng 12: 3189–3199
Perka C, Schultz O, Spitzer RS, Lindenhayn K, Burmester GR, Sittinger M 2000 Segmental bone repair by tissue-engineered periosteal cell transplants with bioresorable fleece and fibrin scaffolds in rabbits. Biomaterials 21: 1145–1153
Sumita Y, Honda MJ, Ohara T, Tsuchiya S, Sagara H, Kagami H, Ueda M 2006 Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. Biomaterials 27: 3238–3248
Yoo HS, Lee EA, Yoon JJ, Park TG 2005 Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering. Biomaterials 26: 1925–1933
Richards SK, Lear PA, Huskisson L, Saleem MA, Morgan JD 2005 Porcine dermal collagen graft in pediatric renal transplantation. Pediatr Transplant 9: 627–629
Esposito G, Gravante G, Filingeri V, Delogu D, Montone A 2007 Use of hyaluronan dressings following dermabrasion avoids escharectomy and facilitates healing in pediatric burn patients. Plast Reconstr Surg 119: 2346–2347
Shin'oka T, Matsumura G, Hibino N, Naito Y, Watanabe M, Konuma T, Sakamoto T, Nagatsu M, Kurosawa H 2005 Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J Thorac Cardiovasc Surg 129: 1330–1338
Roh JD, Brennan MP, Lopez-Soler RI, Fong PM, Goyal A, Dardik A, Breuer CK 2007 Construction of an autologous tissue-engineered venous conduit from bone marrow-derived vascular cells: optimization of cell harvest and seeding techniques. J Pediatr Surg 42: 198–202
Tuggle DW, Mantor PC, Foley DS, Markley MM, Puffinbarger N 2004 Using a bioabsorable copolymer plate for chest wall reconstruction. J Pediatr Surg 39: 626–628
Eppley BL, Morales L, Wood R, Pensler J, Goldstein J, Havlik RJ, Habal M, Losken A, Williams JK, Burstein F, Rozzelle AA, Sadove AM 2004 Resorbable PLLA-PGA plate and screw fixation in pediatric craniofacial surgery: clinical experience in 1883 patients. Plast Reconstr Surg 114: 850–856; discussion 857
Ozawa T, Mickle DA, Weisel RD, Matsubayashi K, Fujii T, Fedak PW, Koyama N, Ikada Y, Li RK 2004 Tissue-engineered grafts matured in the right ventricular outflow tract. Cell Transplant 13: 169–177
Drewa T, Galazka P, Prokurat A, Wolski Z, Sir J, Wysocka K, Czajkowski R 2005 Abdominal wall repair using a biodegradable scaffold seeded with cells. J Pediatr Surg 40: 317–321
Fisher JP, Jo S, Mikos AG, Reddi AH 2004 Thermoreversible hydrogel scaffolds for articular cartilage engineering. J Biomed Mater Res A 71: 268–274
Kaihara S, Matsumura S, Fisher JP 2008 Synthesis and characterization of cyclic acetal based degradable hydrogels. Eur J Pharm Biopharm 68: 67–73
Moreau JL, Kesselman D, Fisher JP 2007 Synthesis and properties of cyclic acetal biomaterials. J Biomed Mater Res A 81: 594–602
Yoon DM, Fisher JP 2006 Chondrocyte signaling and artificial matrices for articular cartilage engineering. Adv Exp Med Biol 585: 67–86
Yoon DM, Hawkins EC, Francke-Carroll S, Fisher JP 2007 Effect of construct properties on encapsulated chondrocyte expression of insulin-like growth factor-1. Biomaterials 28: 299–306
Andriani E, Bugli T, Aalders M, Castelli S, De Luigi G, Lazzari N, Rolli GP 2000 [The effectiveness and acceptance of a medical device for the treatment of aphthous stomatitis. Clinical observation in pediatric age]. Minerva Pediatr 52: 15–20
Ruszymah BH, Chua K, Latif MA, Hussein FN, Saim AB 2005 Formation of in vivo tissue engineered human hyaline cartilage in the shape of a trachea with internal support. Int J Pediatr Otorhinolaryngol 69: 1489–1495
Kobus KF 2007 Cleft palate repair with the use of osmotic expanders: a preliminary report. J Plast Reconstr Aesthet Surg 60: 414–421
Schittkowski MP, Guthoff RF 2006 Injectable self inflating hydrogel pellet expanders for the treatment of orbital volume deficiency in congenital microphthalmos: preliminary results with a new therapeutic approach. Br J Ophthalmol 90: 1173–1177
Bendoriene J, Vogt U 2006 Therapeutic use of silicone hydrogel contact lenses in children. Eye Contact Lens 32: 104–108
Maurer BJ, Kalous O, Yesair DW, Wu X, Janeba J, Maldonado V, Khankaldyyan V, Frgala T, Sun BC, McKee RT, Burgess SW, Shaw WA, Reynolds CP 2007 Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-X-SORB organized lipid complex. Clin Cancer Res 13: 3079–3086
Cohen AJ, Dickerman RD, Schneider SJ 2004 New method of pediatric cranioplasty for skull defect utilizing polylactic acid absorbable plates and carbonated apatite bone cement. J Craniofac Surg 15: 469–472
Velardi F, Amante PR, Caniglia M, De Rossi G, Gaglini P, Isacchi G, Palma P, Procaccini E, Zinno F 2006 Osteogenesis induced by autologous bone marrow cells transplant in the pediatric skull. Childs Nerv Syst 22: 1158–1166
Sunil I, Bond SJ, Nagaraj HS 2006 Primitive neuroectodermal tumor of the sternum in a child: resection and reconstruction. J Pediatr Surg 41: e5–e8
Nikitin AA, Titova NV, Karachunskii GM 2005 [Surgical treatment of cystous lesions of the jaws in children using biocomposite material]. Stomatologiia (Mosk) 84: 40–43
Perry TE, Kaushal S, Sutherland FW, Guleserian KJ, Bischoff J, Sacks M, Mayer JE 2003 Thoracic Surgery Directors Association Award. Bone marrow as a cell source for tissue engineering heart valves. Ann Thorac Surg 75: 761–767; discussion 767
Schmidt D, Breymann C, Weber A, Guenter CI, Neuenschwander S, Zund G, Turina M, Hoerstrup SP 2004 Umbilical cord blood derived endothelial progenitor cells for tissue engineering of vascular grafts. Ann Thorac Surg 78: 2094–2098
Sodian R, Lueders C, Kraemer L, Kuebler W, Shakibaei M, Reichart B, Daebritz S, Hetzer R 2006 Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg 81: 2207–2216
Stuart JD, Kenney JG, Morgan RF 1987 Pediatric burns. Am Fam Physician 36: 139–146
Cassidy C, St Peter SD, Lacey S, Beery M, Ward-Smith P, Sharp RJ, Ostlie DJ 2005 Biobrane versus duoderm for the treatment of intermediate thickness burns in children: a prospective, randomized trial. Burns 31: 890–893
Lang EM, Eiberg CA, Brandis M, Stark GB 2005 Biobrane in the treatment of burn and scald injuries in children. Ann Plast Surg 55: 485–489
Martinez L, Ros Z, Lopez-Gutierrez JC, Diaz M, Quezada B, Perdiguero M, Hernandez F, Rivas S, Tovar JA 2002 [Integra artificial dermis in pediatric reconstructive surgery]. Cir Pediatr 15: 97–100
Kumar RJ, Kimble RM, Boots R, Pegg SP 2004 Treatment of partial-thickness burns: a prospective, randomized trial using Transcyte. ANZ J Surg 74: 622–626
Norbury WB, Jeschke MG, Herndon DN 2005 Tissue engineered fetal skin constructs for pediatric burns. Crit Care 9: 533–534
Author information
Authors and Affiliations
Corresponding author
Additional information
This work was supported by the State of Maryland Department of Business and Economic Development and the National Science Foundation through a CAREER Award (J.P.F., BES 0448684).
Rights and permissions
About this article
Cite this article
Patel, M., Fisher, J. Biomaterial Scaffolds in Pediatric Tissue Engineering. Pediatr Res 63, 497–501 (2008). https://doi.org/10.1203/01.PDR.0b013e318165eb3e
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1203/01.PDR.0b013e318165eb3e
This article is cited by
-
Use of collagen and auricular cartilage in bioengineering: scaffolds for tissue regeneration
Cell and Tissue Banking (2024)
-
Cyclic pressure induced decellularization of porcine descending aortas
Journal of Materials Science: Materials in Medicine (2023)
-
Release kinetics of the model protein FITC-BSA from different polymer-coated bovine bone substitutes
Head & Face Medicine (2019)
-
Dipyridamole-loaded 3D-printed bioceramic scaffolds stimulate pediatric bone regeneration in vivo without disruption of craniofacial growth through facial maturity
Scientific Reports (2019)
-
Minimal modulation of the host immune response to SIS matrix implants by mesenchymal stem cells from the amniotic fluid
Hernia (2017)
