Figure 1 | Pediatric Research

Figure 1

From: Resistance of Young Rat Hepatic Mitochondria to Bile Acid-Induced Permeability Transition: Potential Role of α-Tocopherol

Figure 1

(A) A representative tracing demonstrating age-related resistance to GCDC-induced MPT in 6-days old (•), 10-days old (○), 21-days old (▴), 36-days old (▵), and adult (□) rat mitochondria exposed to 100 μM GCDC (added at 5 min). Note that y axis values do not begin at “0”. (B) Mean values ± SEM of rats of different ages during the time course of MPT induction by 0 μM (▪), 25 μM (□), 50 μM () and 100 μM GCDC (). *p < 0.0001 between adult and all other rat ages for 25–100 μM GCDC by ANOVA analysis. Results were from three separate experiments. (C) Transmission electron microscopy of mitochondria isolated from rats of different ages (days) at end of MPT experiment. Bar in 36 days panel exposed to GCDC represents 1.0 μm.

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