Abstract
The effect of a 20 s sustained inflation (SI) and positive end-expiratory pressure (PEEP) on functional residual capacity (FRC) formation at birth were investigated. Preterm rabbit pups (28 d) were randomized at birth into four groups (n = 6 for each): 1) SI, PEEP 5 cm H2O, 2) no SI, PEEP 5 cm H2O, 3) no SI + no PEEP, 4) SI + no PEEP. FRC and tidal volume (Vt) were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging. Ventilation with a SI and PEEP uniformly aerated the lung and Vt and FRC were recruited by the first tidal inflation. Ventilation without a SI, with PEEP, gradually recruited Vt and FRC with each inflation but aeration was not uniform. Ventilation without a SI or PEEP, gradually recruited Vt, but no FRC. Ventilation with a SI, without PEEP, uniformly aerated the lung and recruited Vt but no FRC. FRC was greater with SI (p = 0.006) during the first minute, but was larger with PEEP than without PEEP throughout the first 7 min (p < 0.0005). Effects of PEEP and SI were additive. In ventilated preterm rabbits at birth, combining a SI and PEEP improved FRC formation and uniformity of lung aeration, but PEEP had the greatest influence.
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Abbreviations
- FRC:
-
functional residual capacity
- PEEP:
-
positive end-expiratory pressure
- PPV:
-
positive pressure ventilation
- SI:
-
sustained inflation
- Vt:
-
tidal volume
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Support was provided by SPring-8 synchrotron facility (Japan), granted under the approval of the SPring-8 Program Review Committee (proposal nos. 2006B0002, 2007A0002).A.B.P. is a recipient of a Ter Meulen Fund grant for working visits, Royal Netherlands Academy of Arts and Sciences, The Netherlands and recipient of a Royal Women's Hospital postgraduate scholarship. M.J.K. is a recipient of an ARC Post-Doctoral Fellowship.
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te Pas, A., Siew, M., Wallace, M. et al. Establishing Functional Residual Capacity at Birth: The Effect of Sustained Inflation and Positive End-Expiratory Pressure in a Preterm Rabbit Model. Pediatr Res 65, 537–541 (2009). https://doi.org/10.1203/PDR.0b013e31819da21b
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DOI: https://doi.org/10.1203/PDR.0b013e31819da21b
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