Abstract
Obesity is associated with elevated blood pressure (BP), insulin resistance, and altered plasma adiponectin levels; the relationship between the biochemical features of obesity and 24-h ambulatory blood pressure (24-h ABP) parameters in adolescents remains unknown. Anthropometric measurements and 24-h ABP monitoring were obtained on 41 obese adolescents with and without type 2 diabetes mellitus (T2DM). Serum adiponectin, high sensitivity C-reactive protein (hs-CRP), lipid profile, insulin, fasting glucose, liver enzymes, Hb A1c (HbA1c), and two random urine samples were obtained for creatinine and microalbumin measurements. The determinants of 24-h systolic (SBP) and diastolic (DBP) BP were examined using multivariate linear regression models with BP parameters as outcome variables. Forty-one obese adolescents were studied. Adiponectin levels were reduced and hs-CRP levels were elevated, and were inversely and significantly correlated (rho = −0.3, p = 0.05). ABP showed blunted nocturnal SBP dipping. Twenty-four hour SBP and DBP indexes were significantly (p < 0.05) and inversely correlated with adiponectin (rho = −0.4 and −0.42), respectively. In multivariate models, lower adiponectin level was independently associated with 24-h SBP and DBP. Adiponectin inversely correlate with ABP parameters in obese adolescents. Larger studies are needed to examine the relationship between adiponectin and mechanisms of BP regulation.
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Abbreviations
- ABPM:
-
ambulatory blood pressure monitoring
- BP:
-
blood pressure
- DBP:
-
diastolic BP
- HbA1c:
-
hemoglobin A1c
- hsCRP:
-
high sensitivity C-reactive protein
- HOMA:
-
homeostasis model assessment of insulin resistance
- LVMI:
-
left ventricular mass index
- SBP:
-
systolic BP
- TG:
-
triglycerides
- T2DM:
-
type 2 diabetes mellitus
- WHR:
-
waist to hip ratio
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Supported by The Kidney and Urology Foundation of America grant number 4272387 (I.F.S.).
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Shatat, I., Freeman, K., Vuguin, P. et al. Relationship Between Adiponectin and Ambulatory Blood Pressure in Obese Adolescents. Pediatr Res 65, 691–695 (2009). https://doi.org/10.1203/PDR.0b013e31819ea776
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DOI: https://doi.org/10.1203/PDR.0b013e31819ea776
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