Abstract
Background: Oral-facial clefts are birth defects in which the tissues of the mouth or lip don't form properly during fetal development. The causes of these birth defects are not well understood, but believe it may be a combination of genetic and environmental factors (drugs, illnesses, and the use of alcohol or tobacco while a woman is pregnant) - multifactorial inheritance.
Aim: To evaluate the incidence, causes and symptoms of oral facial clefts at the children's ward in Stip.
Methods: After birth, cleft lip and palate are diagnosed by physical exam. Special exposure of their mothers during pregnancy indicates that environmental factors increase the risk of cleft lip and palate.
Results: During the past 10 year children with oral facial clefts are borns in series in the same or closer month in the year. We councluded that every year the number od children with oral-facial clefts growing and they were not associated with any syndrome Their parents doesn't have a oral-facial clefts. Children with oral-facial clefts have special problems and complication like feeding difficulties, ear infections and hearing loss.
Conclusion: The obtain results suggest that environmental factors, such as drugs (several different anti-seizure drugs) and maternal smoking, are risk factors for appearance of oral-facial clefts. Cleft lips and palates not associated with a syndrome are caused by a combination of genetic and environmental factors. Other environmental factors that are suspected of playing a role include infections, maternal alcohol use and deficiency of the B vitamin folic acid.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Velickova, N., Gacova, M. 817 Oral-Facial Clefts/The Incidence, Causes and Symptoms at the Children Hospitalized in Children's Ward in Stip. Pediatr Res 68 (Suppl 1), 411 (2010). https://doi.org/10.1203/00006450-201011001-00817
Issue date:
DOI: https://doi.org/10.1203/00006450-201011001-00817