872 Antimicrobial Resistance of Streptococcus Pneumoniae Isolated From Children with Nasopharyngeal Carriage and Infections During the 9-Year Period (1999-2007)

Abstract

Aim: Streptococcus pneumoniae continues to be an important cause of community-acquired respiratory tract infections. Because of increase in its antimicrobial resistance, the surveillance of the local antimicrobial susceptibility of S.pneumoniae should be carried out regularly.

Methods: Streptococcus pneumoniae strains were isolated from children on admission to The Children's Memorial Health Institute, Warsaw, Poland between Jan 1999 and Dec 2007. A total of 784 isolates of S.pneumoniae were collected. Susceptibility to antibiotics was analyzed in two periods: 1999-2002 and 2003-2007. All the strains (185) collected in the first period originated from children with pneumococcal diseases. Of the 599 strains obtained in the second period, 234 were isolated from children with S.pneumoniae infection and 365 from children with nasopharyngeal carriage.

Results and Conclusions: Rate of resistance to penicillin was stable during the whole period of the study (3% vs. 4%). Higher resistance rates to erythromycin (19% vs. 29%), clindamycin (14% vs. 26%) and lower resistance rates to tetracycline (37% vs. 9%) and co-trimoxazole (47% vs. 41%) were observed among isolates obtained in the second period. S.pneumoniae strains isolated from infections and from carriage exhibited similar resistance patterns.

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