Abstract
Aim: The aim of the study was to analyze the type of brain abnormalities in children with severe congenital cytomegaly, using MRI scan.
Material and Methods: Seventeen infants congenitally infected by cytomegalovirus (CMV) hospitalized from 2002 to 2009 yrs were involved in the study. Congenital CMV infection was diagnosed on the basis of clinical signs and symptoms confirmed by detection of DNA CMV in urine and specific antibodies (IgM, IgG) in serum during the first weeks of life. In all MRI of the brain was performed. The mean period of observation was 17 months (ranged from 5 to 60).
Results: MRI findings: different types of malformations of cortical development (agyria, pachygyria, polimicrogyria, subependymal heterotopia) and focal cortical dysplasia in 17 (100%), delayed myelinization in 6 (35,3%), white matter lesions in 7 (41,2%), thin corpus callosum in 5 (30,0%), brain atrophy in 8 (47,0%), cerebellar hypoplasia in 3 (17,6%), ventriculomegaly in 15 (88,2%), schizencephaly in 2 (11,7%) infants. Other findings in CNS visualized by computer tomography: intracranial calcifications in 5 (30,0%), microcephaly in 10 (60,0%). Late sequelae: various degrees of psychomotor retardation 7 (41,2%), epilepsy 8 (47,0%), cerebral palsy 8 (47,0%).
Conclusions:
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1. Cortical dysplasia revealed in all infants as a result of cerebral migration defect indicate on fetal CMV infection during the first half of gestation.
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2. Cortical malformations and other disorders of the brain were responsible for epilepsy, cerebral palsy and developmental delay.
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3. MRI is the method of choice in evaluating brain lesions in children with cytomegaly.
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Milewska-Bobula, B., Lipka, B., Zebrowska, J. et al. 876 Disorders of the Brain Revealed by Magnetic Resonance Imaging (MRI) in Infants with Severe Congenital Cytomegaly. Pediatr Res 68 (Suppl 1), 440 (2010). https://doi.org/10.1203/00006450-201011001-00876
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DOI: https://doi.org/10.1203/00006450-201011001-00876
