883 Considerations on Five Cases of Newborns From A/H1N1 Infected Mothers

Abstract

Introduction: A/H1N1 virus influenza represents a global health issue, causing more than 17000 deaths so far. The purpose of this paper is to present five cases of newborns from A/H1N1 infected women and the evolution of clinical aspects in mother-child couples.

Material and Methods: The authors analyzed the evolution of clinical, biological, inflammatory parameters and the A/H1N1 viral detection tests of the mothers' nasal secretions.

Results: There have been five cases of newborns from A/H1N1 infected women between November 2009 - February 2010 in our Centre.

Mothers' disease had the clinical aspect of viral infection. In all cases, the virological tests detected A/H1N1 virus in nasal secretions. Two women presented influenza symptoms which started 2 and 3 weeks, respectively, before the extraction of the foetus. Despite prolonged mechanical ventilation, they died shortly after surgery. Three women needed CPAP, with favourable outcome.

The newborns' mean gestational age was 35 weeks. All newborns (3 males, 2 females) were extracted by caesarean section. Apgar scores were 5-8 in 4 cases and 2 for one newborn which needed complex resuscitation at birth. Two newborns developed congenital pneumonia-like clinical and radiological signs. The virological tests did not detect A/H1N1 virus in the nasal secretions of the newborns. The outcome of the newborns was favourable in all cases.

Conclusions: A/H1N1 virus infection caused the early extraction of the foetus. The delay of the caesarean section caused a poor outcome for the mother. The newborns had negative viral detection tests and a slowly favourable outcome.

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