899 Prevalence of Human Metapneumovirus (HMPV) in Children with Respiratory Disease Symptoms - Shiraz-Iran

Abstract

Background: Human metapneumovirus (hMPV) is one of the main causes of viral lower and upper respiratory tract infections which was the first isolated in 2001 from children with acute respiratory tract infections. hMPV have been classified in the Pneumovirinae subfamily within the Paramyxoviridae family. Since then, increasingly world wide investigators have been reported that hMPV is a leading cause of lower respiratory tract infections in children.

Objective: In this study we tried to determine the prevalence of human pneumovirus in hospitalized children with asthma, wheezing and bronchiolitis symptoms.

Methods: Nasal pharyngeal swabs obtained from 155 children aged 1-60 months, hospitalized between February 2009 - March 2010, (this infection occurred predominantly from February to July). Collected samples were tested for the hMPV by RTPCR with specific designed primer and evaluated with the gel electrophoresis.

Findings: In this study the result of amplified specific regions determined hMPV in 22 (14.2 %) of 155 patients suffering from respiratory symptoms.

Conclusion: Comparison of the results in this study and other studies it has been concluded although over the 70% of the respiratory disease could be result of common respiratory viruses like RSV, rhinovirus, Parainfluenza virus, adenovirus and influenza viruses but some viruses like metapneumovirus can be either important in disease of children with upper and lower respiratory symptoms and must be consider and determine it's etiologic role in lung disorders like the other alternatives.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD