1312 Pulmonary Infections in Children with Cystic Fibrosis

Abstract

Introduction: Cystic Fibrosis (CF) is the mostcommon inherited life shortening disease amongwhite population but also appears among otherethnic groups and races. CF is autosome recesivedisease and in Europe the most frequent mutationis delta F508. Disease is polysistemic and involsin first place respiratory system, gastrointestinalsystem, failure to thrive and other signs.

Aim of study: Presentation of cases treated inour ward, some clinical features focusing in mostfrequent infections which we found in our patients during period of 2000-2008.

Material and Methods: For the tudy we usedpatients records, outpatients records, hematologiclaboratory findings, microbiology analyses, chest Xray.

Results: We treat 32 children with diagnose as CFand19(59.3%) are female and13(40.6%) are male. Under 1 year of age are 8 children(25%), from 1till 5 years of age are18 children(56.2%), from 5till 10 years are 4 children(12.5%) and above 10years 2 children(0.62%). Our diagnose was basedin clinical features, sweat test and genetic mutation. In 6 children we had a positive family history(18%). Frequency of their admission is as follows: 10children(31.2%) were admitted once a year, 9children(28.1%) we admitted 2 or 3 times a year and16 children(50%) were admitted more than threetimes during one year. Infectons that we isolated inour children is follows:at 3 children(9.3%)was isolatedStreptococcus pneumonae, at 5 children(15.6%)Echeria coli, at 3 children (9.3%):Klebsiella, at4 children(12.5%) :Staphylococcus aureus, at2 children(6.2%) :Pseudomonas aeruginosa, at2 children(6.2%):Citrobacter,1 child(3.1%) hadBranhamella. At other children the culture wassterile.

Conclusion: Presented cases realize that theinfection is the common reason for exacerbationand admission in hospital. The agents are commonas we found in literature.

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